Program

Program – PIVAC-24

7:45 REGISTRATION

 

DAY 1 (Thursday, September 26)

1 – Vaccines and Cellulars (I)

Chairs: Per Thor Straten, Wolf Fridman

8:30 – 9:00 Welcome
(Jirina Bartunkova, Graham Pawelec, Luca Vanucci)

9:00 – 9:30 Vaccines and T-cell therapy in solid cancers
(Else Maria Inderberg)

9:30 – 10:00 Improving the efficacy of dendritic cell vaccines
(Daniel Smrž or Dmitry Stakheev)

10:00 – 10:15 Coffee Break

1 – Vaccines and Cellulars (II)

Chairs: Natalia Aptsiauri, Graham Pawelec

10:15 – 10:45 Salvage peptide vaccination in checkpoint resistant lung
cancer
(Marij Welters)

10:45 – 11:15 Melanoma vaccines: Survival benefit and New directions
(Craig Slingluff)

11:15 – 11:45 Lipid nanoparticle-formulated mRNA as cancer therapy
(Damya Laoui)

11:45 – 12:15 Selected Orals

Doggybone™ DNA vaccines targeting cancer associated antigens MAGED4B and FJX1 sensitises cold tumour through enhancing effector T cell recruitment in oral cancer model
(Grace Min Yi Tan)

Synergistic anti-tumor effects of phage-based anti-HER2 vaccination and Palbociclib combination therapy in a Hormone Receptor-positive/HER2-positive breast cancer model
(Junbiao Wang)

12:15 – 13:15 Lunch

2 – Determinants and Predictors

Chairs: Else Maria Inderberg, Radek Spisek

13:15 – 13:45 Determinants of therapeutic responses to immunotherapy
in patients presenting with TLS
(Wolf Fridman)

13:45 – 14:15 Tumor HLA class I alterations: detection and clinical
relevance
(Natalia Aptsiauri)

14:15 – 14:45 Selected Orals

How to improve the efficacy of breast cancer immunotherapy? A TLR2 targeting approach
(Antonino Di Lorenzo)

A cell line model of early high-grade serous ovarian cancer
(Alice Fearn)

14:45 – 15:00 Coffee Break

3 – Checkpoints

Chairs: Marij Welters, Daniel Smrz

15:00 – 15:30 Immune cell dynamics predicting clinical responses to
checkpoint blockade in melanoma
(Graham Pawelec)

15:30 – 16:00 Glyco-immune checkpoints for Immunotherapy of cancer
(Gosse Adema)

16:00 – 16:30 The exercise of tinkering with the immune system
(Per Thor Straten)

16:30 – 16:45 Coffee Break

Chairs: Damya Laoui, Hans-Georg Rammensee

16:45 – 17:15 Challenges of immune-oncology drug development in post
checkpoint inhibitor era
(Radek Spisek)

17:15 – 17:45 C.T.L. presentation: Antigen-specific B cell ImmunoSpot assays can be readily validated – and why that matters
(Paul Lehmann, pre-recorded)

 

18:00 – 19:00 Music Recital
(Jan Kalfus – organ, Jan Pohoraly – pipe)

Program:

Pavel Josef Vejvanovský (1633–1693) – Sonata in G minor A4

Johann Sebastian Bach (1685–1750) – Fantasy and Fugue in G minor
BWV 542

Joseph Haydn (1732–1809) – Andante from Concerto in E flat major
for trumpet and organ

Petr Eben (1929–2007) – Moto ostinato
from Sunday Music

Georg Philipp (1681–1767) – Telemann Concerto in D major
for trumpet and organ

Allegro
Largo
Vivace

19:00 – 22:00 Welcome Dinner  

DAY 2 (Friday, September 27)

8:00 REGISTRATION

4 – Tumor (Immnune) Microenvironment and Resistance (I)

Chairs: Barbara-Ann Guinn, Joerg Wischhusen

8:30 – 9:00 Immune evasion in pancreatic cancer
(Enzo Bronte)

9:00 – 9:30 Immunological configuration of ovarian carcinoma: The
impact on disease outcome and response to
Immunotherapy
(Jitka Palich Fucikova)

9:30 – 10:00 Smoldering inflammation and collagen remodeling
condition the tumor microenvironment immunity
(Luca Vannucci)

10:00 – 10:15 Coffee Break

5 – Tumor (Immnune) Microenvironment and Resistance (II)

Chairs: Barbara Seliger, Viktor Umansky

10:15 – 10:45 Myeloid cells en-RAGE antitumor immunity
(Sue Ostrand-Rosenberg)

10:45 – 11:15 A novel, radiotherapy actionable immunological
mechanism of resistance to CDK4/6 inhibitors in HR+
breast cancer
(Lorenzo Galluzzi)

11:15 – 11:45 Exploring CSPG4 immune-targeting in osteosarcoma
using comparative oncology models
(Federica Cavallo)

11:45 – 12:15 Selected Orals

Investigating the role of the cystine/glutamate antiporter xCT in the extracellular vesicles-mediated modulation of the pre-metastatic niche
(Antonella Iacoviello)

Role of Toll-like receptor 2 in tumor cell autonomous and microbiota-driven chemoresistance in breast cancer
(Chiara Cossu)

12:15 – 13:15 Lunch

6 – New Targets and Approaches

Chairs: Jitka Palich Fucikova, Lorenzo Galluzzi

13:15 – 13:45 Increased complexity of immune escape mechanisms of
tumors
(Barbara Seliger)

13:45 – 14:15 New targets for the treatment of acute leukaemia
(Barbara-Ann Guinn)

14:15 – 14:45 Targeting of MDSC to improve tumor immunotherapy
(Viktor Umansky)

14:45 – 15:15 Tolerogenic onco-fetal proteins as emerging targets for
novel therapies
(Joerg Wischhusen)

15:15 – 15:30 Coffee Break

7 – Strategies

Chairs: Sue Ostrand-Rosenberg, Luca Vannucci

15:30 – 16:00 Dissection of the T-cell response in pancreatic cancer at
the single cell level
(Rienk Offringa)

16:00 – 16:30 Harnessing the pleiotropy of TGF-β to treat diseases
associated with immune dysfunction
(Sophie Lucas)

16:30 – 16:45 Coffee Break

16:45 – 17:45 Selected Orals

The effect of aspartate β-hydroxylase inhibition on cancer immunotherapy
(Michal Smahel)

Spatial immunoprofiling of the tumor tissue in patients with leiomyosarcomas
(Iva Benesova)

Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer
(Lenka Kasikova, Barbora Tunkova)

Chemotherapy drives tertiary lymphoid structures that correlate with ICI-responsive TCF1+CD8+ T cells in metastatic ovarian cancer
(Tereza Lanickova)

 

DAY 3 (Saturday, September 28)

8 – Social Event

Individual sightseeing tour in the centre of Prague
(In case, you are interested in a guided tour, let us know at the registration des­k.)